Conformational Modulation of Sequence Recognition in Synthetic Macromolecules
نویسندگان
چکیده
منابع مشابه
Conformational modulation of sequence recognition in synthetic macromolecules.
The different triplet sequences in high molecular weight aromatic copolyimides comprising pyromellitimide units ("I") flanked by either ether-ketone ("K") or ether-sulfone residues ("S") show different binding strengths for pyrene-based tweezer-molecules. Such molecules bind primarily to the diimide unit through complementary π-π-stacking and hydrogen bonding. However, as shown by the magnitude...
متن کاملElastic models of conformational transitions in macromolecules.
We develop a computationally efficient and physically realistic method to simulate the transition of a macromolecule between two conformations. Our method is based on a coarse-grained elastic network model in which contact interactions between spatially proximal parts of the macromolecule are modelled with Gaussian/harmonic potentials. To delimit the interactions in such models, we introduce a ...
متن کاملOptimal flexibility for conformational transitions in macromolecules.
Conformational transitions in macromolecular complexes often involve the reorientation of leverlike structures. Using a simple theoretical model, we show that the rate of such transitions is drastically enhanced if the lever is bendable, e.g., at a localized hinge. Surprisingly, the transition is fastest with an intermediate flexibility of the hinge. In this intermediate regime, the transition ...
متن کاملRole of conformational dynamics in sequence-specific autoantibody*ssDNA recognition.
11F8 is a sequence-specific monoclonal anti-ssDNA autoantibody isolated from a lupus prone mouse that forms pathogenic complexes with ssDNA, resulting in kidney damage. Prior studies show that specificity is mediated by a somatic mutation from serine at (31)V(H) to arginine. Reversion back to serine in 11F8 resulted in >30-fold decrease in affinity and altered thermodynamic and kinetic paramete...
متن کاملKramers Theory for Conformational Transitions of Macromolecules
Marcello Sega, Pietro Faccioli, 3 Francesco Pederiva, 4 and Henri Orland Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, D-60435 Frankfurt, Germany∗ Dipartmento di Fisica, Università di Trento, Via Sommarive 14, I-38050 Povo (Trento), Italy I.N.F.N Gruppo Collegato di Trento I.N.F.M-Democritos, National Simulation Center, Trieste, Italy Service de Physique Théorique, Centre d’Etu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2011
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja2067115